Aziridinylbenzoquinone RH1

Preferred Label : Aziridinylbenzoquinone RH1;

NCIt synonyms : 2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone;

NCIt definition : A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.;

Molecule name : RH1;

NSC code : 697726;

Details

Origin ID

C29404;

UMLS CUI

C0764430;

Automatic exact mappings (from CISMeF team)
- 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone [MeSH concept]
- 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RH1 benzoquinone [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- DNA Intercalation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Crosslinking [NCIt concept]
- DNA Replication Inhibition [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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