NCIt definition : The tromethamide salt form of lodoxamide, a synthetic mast cell stabilizing compound
with anti-inflammatory activity. Upon administration to the eye, lodoxamide tromethamide
inhibits type I immediate hypersensitivity reaction by preventing the antigen-stimulated
calcium influx into mast cells, thereby inhibiting release of histamine. Lodoxamide
tromethamide also prevents the release of slow-reacting substances of anaphylaxis
(SRS-A) and inhibits eosinophil chemotaxis.;
Semantic type(s)