NCIt related terms : Zestril; N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline, Dihydrate; Prinivil;
NCIt definition : An orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor
with antihypertensive activity. Lisinopril, a synthetic peptide derivative, specifically
and competitively inhibits ACE, which results in a decrease in the production of the
potent vasoconstrictor angiotensin II and, so, diminished vasopressor activity. In
addition, angiotensin II-stimulated aldosterone secretion by the adrenal cortex is
decreased which results in a decrease in sodium and water retention and an increase
in serum potassium.;
Alternative definition : NCI-GLOSS: A drug used to treat high blood pressure and certain heart conditions.
It is also being studied in the prevention and treatment of side effects caused by
some anticancer drugs. It blocks certain enzymes that cause blood vessels to constrict
(narrow). It is a type of angiotensin-converting enzyme (ACE) inhibitor.;
UNII : E7199S1YWR;
InChIKey : CZRQXSDBMCMPNJ-ZUIPZQNBSA-N;
CAS number : 83915-83-7;
Drug name : Prinivil; Zestril;
Chemical formula : C21H31N3O5.2H2O;
ChEBI ID : CHEBI:6503;
Codes from synonyms : 32058; CDR0000662968; CDR0000662967; CDR0000662970;