Preferred Label : Fluocinonide;
NCIt synonyms : (6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;
NCIt definition : A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory
and antipruritic activities. Fluocinonide binds the glucocorticoid receptor, followed
by translocation of the ligand-receptor complex to the nucleus and transcription activation
of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor
induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha,
thereby preventing phospholipase translocation to the perinuclear membrane and subsequent
release and conversion of arachidonic acid to inflammatory prostaglandins. In addition,
MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade
resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally,
fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition
of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.;
UNII : 2W4A77YPAN;
InChIKey : WJOHZNCJWYWUJD-IUGZLZTKSA-N;
CAS number : 356-12-7;
Drug name : Lidex; Vanos;
Chemical formula : C26H32F2O7;
NSC code : 101791;
Codes from synonyms : 06873;
Origin ID : C29056;
UMLS CUI : C0016299;
See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
