Fluocinonide - CISMeF

Preferred Label : Fluocinonide;

NCIt synonyms : (6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;

NCIt definition : A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activities. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.;

UNII : 2W4A77YPAN;

InChIKey : WJOHZNCJWYWUJD-IUGZLZTKSA-N;

CAS number : 356-12-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 356-12-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Lidex; Vanos;

Chemical formula : C26H32F2O7;

NSC code : 101791;

Codes from synonyms : 06873;

Details

Origin ID

C29056;

UMLS CUI

C0016299;

Automatic exact mappings (from CISMeF team)
- Fluocinonide [ICHI extension code]
See also inter- (CISMeF)
- Product containing fluocinonide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Fluocinonide [ICD-11 Extension code]
- Fluocinonide (substance) [SNOMED CT concept]
- Product containing fluocinonide (medicinal product) [SNOMED CT concept]
- fluocinonide [ATC Code]
- fluocinonide [ATC Code]
- fluocinonide [Substance BNPC]
- fluocinonide [MeSH concept]
- fluocinonide [MeSH Descriptor]
- fluocinonide, nos [SNOMED Notion]
Validated automatic mappings to BTNT
- fluocinonide [ATC Code]
- fluocinonide [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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