Preferred Label : Fluocinolone Acetonide;
NCIt synonyms : (6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;
NCIt definition : The acetonide salt form of fluocinolone, a synthetic fluorinated corticosteroid with
antiinflammatory, antipruritic and vasoconstrictive properties. Fluocinolone is a
glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors
and subsequently translocates to the nucleus where it initiates the transcription
of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase
A2, thereby blocking the release of arachidonic acid from membrane phospholipids and
preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators
of inflammation. Fluocinolone exerts its vasoconstrictive effect through inhibition
of nitric oxide synthase, thereby blocking nitric oxide production and effectively
diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced
blood flow.;
UNII : 0CD5FD6S2M;
InChIKey : FEBLZLNTKCEFIT-VSXGLTOVSA-N;
CAS number : 67-73-2;
Chemical formula : C24H30F2O6;
NSC code : 92339;
Codes from synonyms : 02011;
Origin ID : C29055;
UMLS CUI : C0016298;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
