Fluocinolone Acetonide

Preferred Label : Fluocinolone Acetonide;

NCIt synonyms : (6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;

NCIt definition : The acetonide salt form of fluocinolone, a synthetic fluorinated corticosteroid with antiinflammatory, antipruritic and vasoconstrictive properties. Fluocinolone is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation. Fluocinolone exerts its vasoconstrictive effect through inhibition of nitric oxide synthase, thereby blocking nitric oxide production and effectively diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced blood flow.;

UNII : 0CD5FD6S2M;

InChIKey : FEBLZLNTKCEFIT-VSXGLTOVSA-N;

CAS number : 67-73-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 67-73-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C24H30F2O6;

NSC code : 92339;

Codes from synonyms : 02011;

Details

Origin ID

C29055;

UMLS CUI

C0016298;

Automatic exact mappings (from CISMeF team)
- Fluocinolone (acetonide) [ICHI extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Fluocinolone acetonide [ICD-11 Extension code]
- Fluocinolone acetonide (substance) [SNOMED CT concept]
- fluocinolone acetonide [ATC Code]
- fluocinolone acetonide [ATC Code]
- fluocinolone acetonide [ATC Code]
- fluocinolone acetonide [ATC Code]
- fluocinolone acetonide [Substance BNPC]
- fluocinolone acetonide [MeSH concept]
- fluocinolone acetonide [MeSH Descriptor]
- fluocinolone acetonide [SNOMED Notion]
Validated automatic mappings to BTNT
- fluocinolone acetonide [ATC Code]
- fluocinolone acetonide [ATC Code]
- fluocinolone acetonide [ATC Code]
- fluocinolone acetonide [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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