Preferred Label : Fluocinolone;
NCIt synonyms : 6-alpha-Fluorotriamcinolone; 6-alpha,9-Difluoro-11-beta,16-alpha-17,21-tetrahydroxypregna-1,4-diene-3,20-dione; Flucinolone;
NCIt definition : A synthetic glucocorticoid with anti-inflammatory and antipruritic activities. Fluocinolone
binds the glucocorticoid receptor, followed by translocation of the ligand-receptor
complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive
elements. Lipocortin-1 is one factor induced by fluocinolone that interacts with and
inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation
to the perinuclear membrane and subsequent release and conversion of arachidonic acid
to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby
preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects
via Jun N-terminal kinase and c-Jun. Finally, fluocinolone binds to and inhibits nuclear
factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription
and subsequent prostaglandin synthesis.;
UNII : CT1IX58L9S;
InChIKey : UUOUOERPONYGOS-CLCRDYEYSA-N;
CAS number : 807-38-5;
Chemical formula : C21H26F2O6;
ChEBI ID : CHEBI:5108;
Origin ID : C29053;
UMLS CUI : C0060507;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
