NCIt definition : A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase
(ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility.
This agent also acts directly on the atrioventricular node to suppress conduction,
thereby slowing conduction velocity. Apparently due to its effects on intracellular
calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving
mitochondrial cytochrome c and caspases 8 and 3. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to treat irregular heartbeat and some types of heart failure.
It is also being studied in the treatment of some types of cancer. Digoxin helps the
heart work normally by controlling the amount of calcium that goes into the heart
muscle. It also may kill cancer cells and make them more sensitive to anticancer drugs.
It is a type of cardiac glycoside.;
UNII : 73K4184T59;
InChIKey : LTMHDMANZUZIPE-PUGKRICDSA-N;
CAS number : 20830-75-5;
Drug name : Lanoxin; Cardiogoxin;
Chemical formula : C41H64O14;
NSC code : 95100;
ChEBI ID : CHEBI:4551;
Codes from synonyms : CDR0000593103; CDR0000476342;
Semantic type(s)