Lamivudine/Zidovudine

Preferred Label : Lamivudine/Zidovudine;

Obsolete resource : true;

NCIt synonyms : Lamivudine Zidovudine;

NCIt definition : A combination of two synthetic nucleoside analogues with synergistic antiviral properties. Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP); zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). These active metabolites inhibit human immunodeficiency virus (HIV) viral reverse transcriptase (RT) by incorporating into viral DNA and terminating viral DNA chain elongation. (NCI04);

Concept status : Obsolete_Concept;

Drug name : Combivir;

Details

Origin ID

C28939;

UMLS CUI

C0717880;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
- Therapeutic or Preventive Procedure [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing lamivudine and zidovudine (medicinal product) [SNOMED CT concept]
- lamivudine, zidovudine drug combination [MeSH concept]
- lamivudine, zidovudine drug combination [MeSH Supplementary Concept]
- zidovudine and lamivudine [ATC Code]
Validated automatic mappings to BTNT
- zidovudine and lamivudine [ATC Code]
chemotherapy_regimen_has_component
- Lamivudine [NCIt concept]
- Zidovudine [NCIt concept]

Keyword's position in hierarchy(ies) :

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