" /> Lamivudine - CISMeF





Preferred Label : Lamivudine;

NCIt synonyms : 3TC; 3'-Thia-2',3'-dideoxycytidine; 2',3'-Dideoxy-3'-thiacytidine; 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone; LAM;

NCIt definition : A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to treat infection caused by viruses.;

UNII : 2T8Q726O95;

InChIKey : JTEGQNOMFQHVDC-NKWVEPMBSA-N;

CAS number : 134678-17-4;

Drug name : Epivir;

Molecule name : (-)-BCH-189; GR109714X;

Chemical formula : C8H11N3O3S;

ChEBI ID : CHEBI:63577;

Codes from synonyms : CDR0000045519; 293;

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08/05/2025


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