Anagrelide - CISMeF

Preferred Label : Anagrelide;

NCIt definition : A synthetic quinazoline derivative, Anagrelide reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04);

Alternative definition : NCI-GLOSS: A drug that is used to decrease the number of platelets in the blood in order to prevent blood clotting.;

UNII : K9X45X0051;

InChIKey : OTBXOEAOVRKTNQ-UHFFFAOYSA-N;

CAS number : 68475-42-3;

Chemical formula : C10H7Cl2N3O;

ChEBI ID : CHEBI:142290;

Codes from synonyms : CDR0000302451; 32;

Details

Origin ID

C28825;

UMLS CUI

C0051809;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Anagrelide (substance) [SNOMED CT concept]
- Product containing anagrelide (medicinal product) [SNOMED CT concept]
- anagrelide [ATC Code]
- anagrelide [MeSH concept]
- anagrelide [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- anagrelide [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Anagrelide Hydrochloride [NCIt concept]
- Anagrelide Hydrochloride Anhydrous [NCIt concept]
is_free_acid_or_base_form_of
- Anagrelide Hydrochloride [NCIt concept]
- Anagrelide Hydrochloride Anhydrous [NCIt concept]

Keyword's position in hierarchy(ies) :

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