Preferred Label : General Transcription Factor 3B 90-kD Subunit;
Obsolete resource : true;
NCIt synonyms : Transcription Factor IIIB 90-kD Subunit; General Transcription Factor IIIB 90kD Subunit; Transcription Initiation Factor IIIB; BRF1 Homolog; BRF; TATA Box Binding Protein (TBP)-Associated Factor 3C; TF3B90; BRF1; GTF3B 90-kD Subunit; TFIIIB90; BRF1 Homolog Subunit of RNA Polymerase III Transcription Initiation Factor IIIB; TAF3B2; hBRF; B-Related Factor 1; TATA Box-Binding Protein-Associated Factor RNA Polymerase III Subunit 2; TBP-Associated Factor RNA Polymerase III 90kD; TATA Box Binding Protein (TBP)-Associated Factor RNA Polymerase III Subunit 2; TAFIII90; GTF3B; TAF3C;
NCIt definition : Encoded by human BRF1 Gene (TFIIB Family), alternative isoforms 1 (677-aa, 74-kD),
2 (134-aa, altered N- and C-termini), 3 (473-aa, shorter N-terminus), and 4 (242-aa)
of General Transcription Factor 3B 90-kD Subunit function at different promoters on
tRNA, 5S rRNA, and other small RNA genes. Related to GTF2B (N-terminus), GTF3B contains
a highly charged region and HMG2-related region. Essential for transcription initiation,
GTF3B (C-terminus) binds TBP (collectively, TFIIIB) as one of three RNA polymerase
III transcription factor subunits. Following GTF3A or GTF3C recognition of promoter
elements, GTF3B and RNA polymerase III bind sequentially. (NCI);
Concept status : Retired_Concept;
GenBank Accession Number : NM_001519;
Origin ID : C28713;
OMIM relation
- Semantic type(s)
