Preferred Label : Asparaginase;

NCIt synonyms : Asparaginase-E.Coli; Lcf-ASP; Asparaginase II; ASP-1; L-ASP; L-Asparagine Amidohydrolase;

NCIt related terms : Leunase; Leucogen; Elspar; L-Asnase; L-asparaginase; Kidrolase; Colaspase;

NCIt definition : An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity.;

Alternative definition : NCI-GLOSS: A drug that is used to treat acute lymphoblastic leukemia (ALL) and is being studied in the treatment of some other types of cancer. It is an enzyme taken from the bacterium Escherichia coli (E. coli). It breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow.;

UNII : G4FQ3CKY5R;

CAS number : 9015-68-3;

Drug name : Kidrolase; Serasa; L-Asnase; Paronal; Laspar; Leucogen; Leunase; Elspar; Spectrila;

Molecule name : Re-82-TAD-15; MK-965;

NSC code : 109229;

Codes from synonyms : NSC0109229; CDR0000045339; CDR0000601030; CDR0000601031; NSC0174950; 45;

Details


Keyword's position in hierarchy(ies) : arborescence

Main resources

You can consult :


https://pgtmsite.files.wordpress.com/2024/01/pegasparaginase_es_20090423.pdf
2009
Canada
drug information
polyox WSR-N 60
Asparaginase
asparaginase
Percutaneous Endoscopic Gastrostomy
asparaginase
polyethylene glycols
pneumoencephalography
Polyethylene Glycol

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08/05/2025


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