Nitric Oxide Synthetase

Preferred Label : Nitric Oxide Synthetase;

NCIt synonyms : EC 1.14.13.39; NADPH-Diaphorase; Nitric-Oxide Synthase; Nitric Oxide Synthase; NO Synthase; NOS Family; Nitric Oxide Synthase Family;

NCIt definition : Expressed in various cell types, Nitric Oxide Synthases (NOS Family) are constitutive or inducible calcium/calmodulin stimulated homodimers stabilized by BH4 that bind FAD and FMN cofactors, generally contain a flavodoxin-like domain, and synthesize reactive free radical nitric oxide messenger from L-arginine. NO can act as a neurotransmitter and has antimicrobial and antitumoral activities in macrophages. IL12 requires NOS to stimulate tyrosine-phosphorylation of STAT4 by TYK2 in NK cytotoxicity. Vascular NO (endothelia) inhibits muscle contraction through a cGMP pathway, inhibits platelet aggregation, and mediates VEGF-induced angiogenesis. Endothelial AKT phosphorylates and enhances NOS activity. Potentially influencing energy balance, NO can trigger cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI);

Details

Origin ID

C28511;

UMLS CUI

C0132555;

Automatic exact mappings (from CISMeF team)
- Family [LOINC System]
- Family (social concept) [SNOMED CT concept]
- NADPH dehydrogenase [MeSH concept]
- NADPH dehydrogenase [MeSH Descriptor]
- NOA1 protein, arabidopsis [MeSH Supplementary Concept]
- NOS1 protein, human [MeSH Supplementary Concept]
- NOS2 protein, human [MeSH Supplementary Concept]
- NOS3 protein, human [MeSH Supplementary Concept]
- Nos1 protein, mouse [MeSH Supplementary Concept]
- Nos1 protein, rat [MeSH Supplementary Concept]
- Nos2 protein, mouse [MeSH Supplementary Concept]
- Nos2 protein, rat [MeSH Supplementary Concept]
- Nos3 protein, mouse [MeSH Supplementary Concept]
- Nos3 protein, rat [MeSH Supplementary Concept]
- Reduced nicotinamide adenine dinucleotide phosphate dehydrogenase (substance) [SNOMED CT concept]
- family, nos [SNOMED Notion]
- nitric oxide associated 1 [HGNC gene]
- nitric oxide synthase type i [MeSH Descriptor]
- nitric oxide synthase type ii [MeSH Descriptor]
- nitric oxide synthase type iii [MeSH Descriptor]
Currated CISMeF NLP mapping
- nitric oxide synthase [MeSH Descriptor]
- nitric oxide synthase [MeSH concept]
False automatic mappings
- Nitric-oxide synthase (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Nitric-oxide synthase (substance) [SNOMED CT concept]
- nitric oxide synthase [MeSH concept]
- nitric oxide synthase [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Methylene Blue Oral Rinse [NCIt concept]

Keyword's position in hierarchy(ies) :

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