NCIt definition : An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce
enough of the hormone cortisol and in some cases, the hormone aldosterone. It may
be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency)
or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).;
Alternative definition : CTCAE: A disorder that occurs when the adrenal cortex does not produce enough of the
hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder
of the adrenal cortex as in Addison's disease or primary adrenal insufficiency.; NICHD: Subnormal concentration of cortisol, with or without mineralocorticoid insufficiency.;