Antisense Oligonucleotide GTI-2040

Preferred Label : Antisense Oligonucleotide GTI-2040;

NCIt related terms : GTI-2040;

NCIt definition : A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase. GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks the production of a protein called ribonucleotide reductase, which helps cells make DNA. This may kill cancer cells that need ribonucleotide reductase to grow. It may also make cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of ribonucleotide reductase inhibitor.;

UNII : 5WY0FWR2CF;

CAS number : 236391-66-5;

Molecule name : GTI-2040;

NSC code : 722929;

Codes from synonyms : 50539; CDR0000306501;

Details

Origin ID

C26652;

UMLS CUI

C1142995;

Currated CISMeF NLP mapping
- GTI2040 [MeSH Supplementary Concept]
- GTI2040 [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GTI2040 [MeSH concept]
- GTI2040 [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- RNA Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Ribonucleoside-Diphosphate Reductase M2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Capecitabine/GTI-2040 [NCIt concept]
- Cytarabine/GTI-2040 [NCIt concept]
- Docetaxel/GTI-2040 [NCIt concept]

Keyword's position in hierarchy(ies) :

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