NCIt definition : A murine IgG1 monoclonal anti-idiotype antibody, containing a variable antigen-binding
region that functionally mimics the three-dimensional structure of a specific epitope
on the ovarian cancer tumor-associated antigen CA-125, with potential antineoplastic
activity. With a variable antigen-binding region that acts as a surrogate antigen
for CA-125, abagovomab may stimulate the host immune system to elicit humoral and
cellular immune responses against CA-125-positive tumor cells, resulting in inhibition
of tumor cell proliferation.;