T-Cell Receptor Gamma Locus

Preferred Label : T-Cell Receptor Gamma Locus;

NCIt synonyms : TCRG; T-Cell Receptor Gamma Gene; T-Cell Rearranging Gene, Gamma; T-Cell Receptor, Gamma Cluster;

NCIt related terms : TRG;

NCIt definition : This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink);

GenBank Accession Number : NG_001336;

Details

Origin ID

C26421;

UMLS CUI

C0524892;

Currated CISMeF NLP mapping
- Genes, T-Cell Receptor gamma [MeSH concept]
- genes, T-Cell receptor gamma [MeSH Descriptor]
HGNC gene
- T cell receptor gamma locus [HGNC gene]
OMIM relation
- T-cell receptor gamma chain constant region 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- Genes, T-Cell Receptor gamma [MeSH concept]
- T cell receptor gamma locus [HGNC gene]
- genes, T-Cell receptor gamma [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Reference Gene Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- T-Cell Receptor Gamma Chain [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 7p15-p14 [NCIt concept]
gene_involved_in_molecular_abnormality
- Absence of Biallelic TCRgamma Deletion [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]
- T-Cell Receptor Gamma Gene Rearrangement [NCIt concept]
gene_plays_role_in_process
- Antibacterial Response [NCIt concept]
- Immune System Process [NCIt concept]
- T-Cell Activation [NCIt concept]
genetic_biomarker_related_to
- T-Cell Receptor Gamma-Delta [NCIt concept]
- TCR Gamma-Delta Positive [NCIt concept]

Keyword's position in hierarchy(ies) :

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