Preferred Label : GDNF Family Receptor Alpha-2;
NCIt synonyms : GDNF Receptor Beta; GDNFR-Beta; PI-Linked Cell-Surface Accessory Protein; Glial Cell Line-Derived Neurotrophic Factor Receptor Beta; Glial Cell Line Derived Neurotrophic Factor Receptor, Beta; NTNRA; RETL2; TGF-Beta Related Neurotrophic Factor Receptor 2; GDNF Family Receptor Alpha 2; TRN Receptor, GPI-Anchored; RET Ligand 2; GFRA2; TRNR2; NTNR-Alpha; GDNFRB; Neurturin Receptor Alpha; GFR-Alpha 2; GFRA2 Protein; NRTNR-ALPHA; GDNFR-Alpha-2; GFR-Alpha-2; GDNF Receptor Alpha-2;
NCIt definition : GDNF family receptor alpha-2 protein (464 aa, 52 kDa) is encoded by the human GFRA2
gene. This protein plays a role in neurotropin signaling.;
NCIt note : GDNF Family Receptor Alpha 2, encoded by the human GFRA2 gene, is a member of the
Glial Cell Line-Derived Neurotrophic Factor (GDNF) Receptor family. GDNF and neurturin
(NTN) are two structurally related, potent neurotrophic factors that play key roles
in the control of neuron survival and differentiation. GFRA2 is required for the development
of the myenteric nerve plexus. This protein is a glycosylphosphatidylinositol(GPI)-linked
cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine
kinase receptor. This receptor acts preferentially as a receptor for NTN compared
to its other family member, GDNF Family Receptor Alpha 1. Two alternatively spliced
transcript variants, long and short, have been described for this gene but their full
length nature is not known. The short form is found in brain and placenta. This gene
is a candidate gene for RET-associated diseases. (From LocusLink, OMIM, Swiss-Prot
and NCI);
Origin ID : C26389;
UMLS CUI : C1457885;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
