Microtubule-Associated Protein RP/EB Family Member 1

Preferred Label : Microtubule-Associated Protein RP/EB Family Member 1;

NCIt synonyms : Adenomatous Polyposis Coli-Binding Protein EB1; MAPRE1; APC-Binding Protein EB1; APC-Binding Protein-EB1;

NCIt definition : Microtubule-associated protein RP/EB family member 1 (268 aa, 30 kDa) is encoded by the human MAPRE1 gene. This protein is involved in microtubule dynamics.;

NCIt note : Encoded by human MAPRE1 Gene (MAPRE/RP/EB Family), 268-aa 30-kDa Microtubule-Associated Protein RP/EB Family Member 1 contains a CH domain and a C-terminal domain that binds to APC. In interphase, MAPRE1 localizes to microtubules (growing ends); during mitosis, MAPRE1 is associated with centrosomes and spindle microtubules. MAPRE1 also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. MAPRE1 also interacts with TERF1. MAPRE1 is likely involved in regulation of microtubule structures, microtubule polymerization, spindle function, and chromosome stability.;

Details

Origin ID

C26380;

UMLS CUI

C1332099;

OMIM relation
- Microtubule-associated protein, rp/eb family, member 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- MAPRE1 protein, human [MeSH Supplementary Concept]
- MAPRE1 protein, human [MeSH concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- MAPRE1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plus End of the Microtubule [NCIt concept]
gene_product_has_biochemical_function
- Microtubule Associated Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Microtubule Polymerization [NCIt concept]

Keyword's position in hierarchy(ies) :

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