Digitoxin - CISMeF

Preferred Label : Digitoxin;

NCIt synonyms : Cardidigin; Crystalline Digitalin;

NCIt related terms : CP4071; (3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide;

NCIt definition : A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI);

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer.;

UNII : E90NZP2L9U;

InChIKey : WDJUZGPOPHTGOT-XUDUSOBPSA-N;

CAS number : 71-63-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 71-63-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Crystodigin;

Molecule name : CP4071;

Chemical formula : C41H64O13;

NSC code : 7529;

ChEBI ID : CHEBI:28544;

Codes from synonyms : 01276; CDR0000045028;

Details

Origin ID

C2634;

UMLS CUI

C0012258;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Digitoxin [ICD-11 Extension code]
- Digitoxin [LOINC component]
- Digitoxin (substance) [SNOMED CT concept]
- Product containing digitoxin (medicinal product) [SNOMED CT concept]
- digitoxin [ATC Code]
- digitoxin [Substance BNPC]
- digitoxin [SNOMED Notion]
- digitoxin [MeSH concept]
- digitoxin [MeSH Descriptor]
Validated automatic mappings to BTNT
- digitoxin [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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