Preferred Label : Immunoglobulin Class Switch Recombination;
NCIt synonyms : Immunoglobulin Isotype-Switch Recombination; Immunoglobulin Switch Recombination; Switch Recombination;
NCIt definition : Any process of gene rearrangement in which one immunoglobulin heavy chain constant
coding region is exchanged for another, with the loss of the intervening region, resulting
in an altered profile of effector molecule interactions for the antibody produced.
During this process the variable coding region of the heavy chain remains unchanged,
thus retaining antigen specificity. Immunoglobulin class switch recombination is involved
in the maturation of an immune respone toward a particular antigen.;
Origin ID : C26279;
UMLS CUI : C1512667;
Semantic type(s)
- biological_process_has_initiator_process
- biological_process_is_part_of_process
