Cardiotrophin-1

Preferred Label : Cardiotrophin-1;

NCIt synonyms : Cardiophin 1; CTF1; Cardiotrophin 1;

NCIt definition : Cardiotrophin-1 (201 aa, 21 kDa) is encoded by the human CTF1 gene. This protein plays a role in the neuromuscular development.;

NCIt note : Cardiotrophin-1 was cloned via its ability to potently induce cardiac myocyte hypertrophy in vitro. It is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and interleukin 6 (IL6). Several members of this family that are known to signal through the transmembrane protein gp130 stimulate cardiac myocyte hypertrophy, which suggeste that the gp130 signaling pathway may play a role in cardiac hypertrophy. (OMIM);

NCI Metathesaurus CUI : CL1399073;

Details

Origin ID

C26086;

UMLS CUI

C5226077;

Automatic exact mappings (from CISMeF team)
- CTF-1 transcription factor [MeSH Supplementary Concept]
- Cardiotrophin 1 [OMIM gene]
- cardiotrophin 1 [HGNC gene]
Currated CISMeF NLP mapping
- cardiotrophin 1 [MeSH concept]
- cardiotrophin 1 [MeSH Supplementary Concept]
OMIM relation
- Cardiotrophin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CTF1 protein, human [MeSH Supplementary Concept]
- cardiotrophin 1 [MeSH concept]
- cardiotrophin 1 [MeSH Supplementary Concept]
gene_encodes_gene_product
- CTF1 Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_expressed_in_tissue
- Heart [NCIt concept]
- Ovary [NCIt concept]
- Prostate Gland [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Cytokine [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- NFAT Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Congestive Heart Failure [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Myogenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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