NCIt definition : Cardiotrophin-1 (201 aa, 21 kDa) is encoded by the human CTF1 gene. This protein
plays a role in the neuromuscular development.;
NCIt note : Cardiotrophin-1 was cloned via its ability to potently induce cardiac myocyte hypertrophy
in vitro. It is a member of the family of cytokines that includes leukemia inhibitory
factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and interleukin
6 (IL6). Several members of this family that are known to signal through the transmembrane
protein gp130 stimulate cardiac myocyte hypertrophy, which suggeste that the gp130
signaling pathway may play a role in cardiac hypertrophy. (OMIM);