" /> Cardiotrophin-1 - CISMeF





Preferred Label : Cardiotrophin-1;

NCIt synonyms : Cardiophin 1; CTF1; Cardiotrophin 1;

NCIt definition : Cardiotrophin-1 (201 aa, 21 kDa) is encoded by the human CTF1 gene. This protein plays a role in the neuromuscular development.;

NCIt note : Cardiotrophin-1 was cloned via its ability to potently induce cardiac myocyte hypertrophy in vitro. It is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and interleukin 6 (IL6). Several members of this family that are known to signal through the transmembrane protein gp130 stimulate cardiac myocyte hypertrophy, which suggeste that the gp130 signaling pathway may play a role in cardiac hypertrophy. (OMIM);

NCI Metathesaurus CUI : CL1399073;

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28/05/2025


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