C-Terminal-Binding Protein 2

Preferred Label : C-Terminal-Binding Protein 2;

NCIt synonyms : Ribeye; C-Terminal Binding Protein-2; C-Terminal Binding Protein 2; CTBP2;

NCIt definition : C-terminal-binding protein 2 (445 aa, 49 kDa) is encoded by the human CTBP2 gene. This protein plays a role in the downregulation of both transcription and cell proliferation.;

NCIt note : C-terminal-binding protein 2 is produced as 2 distinct isoforms. Isoform 1 is a transcriptional repressor that is involved in brown adipose cell differentiation while isoform 2 is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD binding domain similar to NAD -dependent 2-hydroxyacid dehydrogenases. (Entrez Gene and SwissProt);

Details

Origin ID

C26085;

UMLS CUI

C1332651;

OMIM relation
- C-terminal-binding protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- CTBP2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_expressed_in_tissue
- Heart [NCIt concept]
- Pancreas [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Positive Regulation of Cell Differentiation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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