Preferred Label : Cerebellar Degeneration-Related Antigen 1;
NCIt synonyms : Cerebellar Degeneration-Related Autoantigen 1; Cerebellar Degeneration-Related Protein (34kD); Cerebellar Degeneration-Related Autoantigen, 34-kD; CDR34; CDR; CDR62A; CDR1; CDR1 Protein; Cerebellar-Degeneration-Related Antigen 1; Cerebellar Degeneration-Related Protein-1 (34kD); Cerebellar Degeneration-Related Protein 1, 34kDa; Cerebellar-Degeneration-Related Antigen-1;
NCIt definition : Cerebellar degeneration-related antigen 1 (262 aa, 31 kDa) is encoded by the human
CDR1 gene. This protein is involved in autoimmune diseases.;
NCIt note : Cerebellar-Degeneration-Related Antigen 1, encoded by the human CDR1 gene, is one
of the target molecules recognized by autoantibodies directed against neuronal proteins
in patients with paraneoplastic cerebellar degeneration, which occurs in association
with small cell carcinoma of the lung, neoplasms of the breast and ovary, and Hodgkin
disease. This protein contains tandem hexapeptide repeats and is expressed in brain,
predominantly in normal neuroectodermal tissues and in certain malignant tumors. (From
LocusLink, Swiss-Prot and NCI); A peptide derived from cerebellar degeneration-related antigen 1, Edratide, is used
to treat lupus.;
Origin ID : C25897;
UMLS CUI : C1437277;
False automatic mappings
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_organism_source
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
