Psoralen - CISMeF

Preferred Label : Psoralen;

NCIt synonyms : Ficusin; 6-hydroxy-5-benzofuranacrylic Acid deta-lacton;

NCIt definition : A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV ( 360 nm) results in the 2 2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids.;

Alternative definition : NCI-GLOSS: A substance from plants that is sensitive to light (or can be activated by light). Psoralens are used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. They are also being studied in the treatment of graft-versus-host disease. Psoralen is a type of furocoumarin. An example of a psoralen is methoxsalen.;

UNII : KTZ7ZCN2EX;

InChIKey : ZCCUUQDIBDJBTK-UHFFFAOYSA-N;

CAS number : 66-97-7;

Chemical formula : C11H6O3;

NSC code : 217989;

ChEBI ID : CHEBI:27616;

Codes from synonyms : NSC0217989; CDR0000044900; NSC0404562;

Details

Origin ID

C2586;

UMLS CUI

C0016072;

Automatic exact mappings (from CISMeF team)
- 7h-furo[3,2-g][1]benzopyran-7-one [Substance BNPC]
- Psoralen nonmedicinal [ICD-11 Extension code]
- Psoralens (medicinal) [ICHI extension code]
- Psoralens (medicinal) [ICD-11 Extension code]
- ficusin [MeSH Descriptor]
- ficusin [MeSH concept]
- psoralen [Blood Transfusion thesaurus concept]
- psoralen A [MeSH concept]
- psoralen A [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Furocoumarins [MeSH Descriptor]
- psoralens [MeSH concept]
False automatic mappings
- Psoralen (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing psoralen (product) [SNOMED CT concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 7h-furo[3,2-g][1]benzopyran-7-one [Substance BNPC]
- Product containing psoralen (product) [SNOMED CT concept]
- Psoralen (substance) [SNOMED CT concept]
- ficusin [MeSH concept]
- ficusin [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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