NCIt synonyms : I 131 Monoclonal Antibody BC8; monoclonal antibody BC8, iodine I 131; iodine I 131 MOAB BC8; MOAB BC8, iodine I 131; I 131 MOAB BC8;
NCIt related terms : Iodine (131I) Apamistamab; IODINE I-131 APAMISTAMAB; iodine I 131 monoclonal antibody BC8;
NCIt definition : A radioimmunoconjugate consisting of BC8, a murine IgG1 anti-CD45 monoclonal antibody
labeled with iodine 131 (I-131), with radioimmunotherapeutic properties. Using monoclonal
antibody BC8 as a carrier for I-131 results in the targeted destruction of cells expressing
CD45. CD45 is tyrosine phosphatase expressed on virtually all leukocytes, including
myeloid and lymphoid precursors in bone marrow and mature lymphocytes in lymph nodes;
it is also expressed on most myeloid and lymphoid leukemic cells, but not on mature
erythrocytes or platelets. (NCI04);
Alternative definition : NCI-GLOSS: A monoclonal antibody that contains the radioactive substance iodine I131.
It is being studied in the treatment of acute myeloid leukemia. Monoclonal antibodies
are made in the laboratory and can locate and bind to cancer cells. Iodine I 131 monoclonal
antibody BC8 binds to the protein CD45, which is found on most white blood cells and
myeloid and lymphoid leukemia cells.;
Currated CISMeF NLP mapping