NCIt related terms : Arzoxifene.HCl; LY353381 hydrochloride;
NCIt definition : The hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic
properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist.
In comparison to other selective estrogen receptor modulators (SERMs), arzoxifene
exhibits greater bioavailability and higher anti-estrogenic potency in the breast
than raloxifene; it exhibits reduced estrogenicity in the uterus compared with either
tamoxifen or raloxifene. This agent may have beneficial effects on bone and the cardiovascular
system.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of osteoporosis and breast cancer.
Arzoxifene hydrochloride is made in the laboratory and binds to estrogen receptors
in the body. It is a type of selective estrogen receptor modulator (SERM).;
UNII : FU88PI0433;
CAS number : 182133-27-3;
Molecule name : LY353381.HCL; SERM-3;
Chemical formula : C28H29NO4S.HCl;
Codes from synonyms : CDR0000579913; 20000; CDR0000045759;
Semantic type(s)