" /> 5 Alpha-Reductase Inhibitor - CISMeF





Preferred Label : 5 Alpha-Reductase Inhibitor;

NCIt synonyms : Steroid 5-alpha-reductase Inhibitor; 5 Alpha-Reductase Inhibitor;

NCIt related terms : 5-alpha reductase inhibitor;

NCIt definition : Any substance that inhibits steroid 5-alpha-reductase, an enzyme that converts testosterone into dihydrotestosterone (DHT). Since DHT has three times greater affinity for androgen receptors than testosterone, inhibition of 5-alpha-reductase results in a strong reduction in the androgenic effects of testosterone.;

Alternative definition : NCI-GLOSS: A substance that blocks an enzyme needed by the body to make dihydrotestosterone (a male sex hormone made from testosterone). Dihydrotestosterone can cause the prostate to grow. 5-alpha reductase inhibitors are used to shrink an enlarged prostate gland and to improve the flow of urine in a condition called benign prostatic hyperplasia (BPH). A 5-alpha reductase inhibitor is a type of enzyme inhibitor.;

ChEBI ID : CHEBI:50781;

Codes from synonyms : CDR0000651169;

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07/05/2025


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