Preferred Label : Estradiol;
NCIt synonyms : 17-beta-Estradiol; 17 Beta-Estradiol; (17beta)-Estra-1,3,5(10)-triene-3,17-diol;
NCIt definition : The most potent form of the naturally occurring steroid sex hormone in humans, produced
by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds
to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus
and pituitary. The receptor-ligand complex promotes gene expression necessary for
the maintenance of fertility and secondary sexual characteristics in females. In addition,
estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability.
Estradiol, the principal intracellular human estrogen, is substantially more active
at the cellular level than its metabolites, estrone and estriol.;
Alternative definition : NCI-GLOSS: A form of the hormone estrogen.;
CAS number : 50-28-2;
ChEBI ID : CHEBI:16469;
Codes from synonyms : CDR0000305990; 00124; 199;
Origin ID : C2295;
UMLS CUI : C0014912;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
