NCIt synonyms : Modified Vaccinia Ankara Encoding Human MUC-1 Antigen and Interleukin-2 Suspension; MVA-MUC1-IL2; MVA-MUC1-IL2 Vaccine;
NCIt related terms : TG4010;
NCIt definition : A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain
encoding human mucin 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating
and antineoplastic activities. Originally developed for the eradication of smallpox,
MVA is a highly attenuated and replication-defective strain incapable of virion assembly
and exerts potent immunostimulatory activity against antigens. Vaccination with mesmulogene
ancovacivec may stimulate the host immune system to mount a humoral and cytotoxic
T lymphocyte (CTL) responses against tumor cells expressing MUC1, a tumor associated
antigen, resulting in tumor cell lysis. Expression of IL-2 augments the specific CTL
response against MUC1 expressing cells.;
Alternative definition : NCI-GLOSS: A substance that is being studied as an anticancer drug.;
Automatic exact mappings (from CISMeF team)