NCIt definition : An isothiocyanate found in cruciferous vegetables with chemopreventive and potential
antitumor activities. Although the mechanism of action is unclear, phenethyl Isothiocyanate
(PEITC) was shown to induce apoptosis in tumor cells, possibly mediated through its
metabolic intermediates, reactive oxygen species (ROS). PEITC also is able to activate
ERK and JNK signal transduction, which in turn induces expression of stress-responsive
genes. Specifically, this agent has been shown to reactivate gene expression of a
detoxification enzyme, glutathione S-transferase that is silenced in prostate carcinoma.;
Alternative definition : NCI-GLOSS: A substance being studied in the prevention of cancer. It is a naturally
occurring compound found in some cruciferous vegetables.;
UNII : 6U7TFK75KV;
InChIKey : IZJDOKYDEWTZSO-UHFFFAOYSA-N;
CAS number : 2257-09-2;
Chemical formula : C9H9NS;
NSC code : 87868;
ChEBI ID : CHEBI:351346;
Codes from synonyms : NSC0087868; CDR0000044910; 00499; CDR0000044447;
Currated CISMeF NLP mapping