" /> Dofequidar Fumarate - CISMeF





Preferred Label : Dofequidar Fumarate;

NCIt related terms : MS 209;

NCIt definition : A synthetic quinoline derivative with multidrug resistance (MDR) modulating properties. Dofequidar fumarate, like many other MDR reversal agents, binds competitively to the drug-binding site of the transmembrane P-glycoprotein efflux pump (P-gp). Once bound to the P-gp efflux pump, dofequidar is transported out of transformed cells by a mechanism similar to that used by cytotoxic drugs, thereby blocking the efflux of these compounds from the cell. Inhibition of the efflux pump by this agent leads to a retention of the cytotoxic drug resulting in increased intracellular drug concentrations, thereby enhancing cytotoxicity. Dofequidar has demonstrated reversal of the MDR phenotype in those cells exposed to various chemotherapeutic agents, such as vinca alkaloids and anthracyclines.;

Alternative definition : NCI-GLOSS: A substance that is being studied for its ability to make cancer cells respond better to chemotherapy drugs to which they have become resistant. It belongs to the family of drugs called quinolone antibiotics.;

UNII : 3DM793MFSE;

CAS number : 158681-49-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 158681-49-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MS-209;

Codes from synonyms : CDR0000044940;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
02/06/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.