Alkylating Agent

Preferred Label : Alkylating Agent;

NCIt synonyms : Alkylating Agents; Alkylator;

NCIt definition : Agents that replace hydrogen atom(s) in biologically active molecules with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cell growth.;

Alternative definition : NCI-GLOSS: A type of drug that is used in the treatment of cancer. It interferes with the cell's DNA and inhibits cancer cell growth.;

ChEBI ID : CHEBI:22333;

Codes from synonyms : CDR0000045589;

Details

Origin ID

C223;

UMLS CUI

C0002073;

Automatic exact mappings (from CISMeF team)
- Alkylating agent (disposition) [SNOMED CT concept]
- Alkylating agents [ICD-11 Extension code]
- alkylation [MeSH concept]
- alkylation [MeSH Descriptor]
- other alkylating agents [ATC Code]
Currated CISMeF NLP mapping
- Alkylating agent (substance) [SNOMED CT concept]
- Product containing alkylating agent (product) [SNOMED CT concept]
- alkylating agent, nos [SNOMED Notion]
- alkylating agents [ATC Code]
- alkylating agents [MeSH Descriptor]
- alkylating agents [MeSH concept]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Alkylating agent (substance) [SNOMED CT concept]
- Alkylating drug [ICD-11 Extension code]
- Product containing alkylating agent (product) [SNOMED CT concept]
- alkylating agent, nos [SNOMED Notion]
- alkylating agents [ATC Code]
- alkylating agents [MeSH concept]
- alkylating agents [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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