Preferred Label : Anti-HER3/Exatecan Antibody-drug Conjugate ENV-501;
NCIt synonyms : Anti-HER3/Exatecan ADC ENV-501; ADC ENV-501; Anti-HER3 ADC ENV-501;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed
against human epidermal growth factor receptor 3 (HER3; ErbB3) conjugated, via a hydrophilic
cleavable linker, to the cytotoxic agent and DNA topoisomerase I inhibitor exatecan,
with potential antineoplastic activity. Upon administration of anti-HER3/exatecan
ADC ENV-501, the anti-HER3 antibody moiety targets and binds to HER3 expressed on
tumor cells. Upon binding, internalization and linker cleavage, exatecan is released
and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and
resulting in DNA damage, cell cycle arrest and apoptosis in tumor cells overexpressing
HER3. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor
tyrosine kinases, is frequently overexpressed in tumors. The hydrophilic linker is
used to overcome the hydrophobicity of conjugated exatecan.;
Molecule name : HMBD 501; ENV 501; ENV-501; HMBD-501;
Origin ID : C218458;
concept_is_in_subset
- has_target
