Dopamine Beta-Hydroxylase

Preferred Label : Dopamine Beta-Hydroxylase;

NCIt synonyms : EC 1.14.17.1; Dopamine Beta-Monooxygenase; DBH;

NCIt definition : Dopamine beta-hydroxylase (617 aa, 69 kDa) is encoded by the human DBH gene. This protein is involved in the hydroxylation of dopamine, which yields norepinephrine.;

NCIt note : Proteolytic cleavage after the membrane-anchor, occurring between glycine 39 and serine-40, leads to the release of soluble dopamine beta-hydroxylase. (UniProt);

Détails

Origin ID

C218448;

OMIM relation
- Dopamine beta-hydroxylase, plasma [OMIM gene]
gene_encodes_gene_product
- DBH Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Intracellular Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Tyrosine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Biogenic Amine Metabolic Process [NCIt concept]
- Copper Chelation [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

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