Preferred Label : PEOX-based Polymer Encapsulated SN-38 FID-022;
NCIt synonyms : Polyethyloxazoline-based Polymer Encapsulated SN-38 FID-022; Nanoencapsulated SN-38 FID-022;
NCIt definition : A nanoparticle-based formulation composed of the poorly water-soluble SN-38 (7-ethyl-10-hydroxy-camptothecin),
a biologically active metabolite of the prodrug irinotecan, encapsulated within branched
polymers composed of polyethyloxazoline (PEOX), with potential antineoplastic activity.
Upon administration of the PEOX-based polymer encapsulated SN-38 FID-022, the nanoparticles
accumulate at the tumor site, due to the unique characteristics of the tumor vasculature,
while avoiding normal, healthy tissue. Once SN-38 is released, it binds to and inhibits
topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA,
resulting in DNA breaks, inhibition of DNA replication, and apoptosis. Compared to
the administration of SN-38 alone, this formulation increases SN-38's solubility and
enhances its tumor tissue penetration and efficacy, while avoiding systemic exposure,
which minimizes its toxicity.;
Molecule name : FID-022; FID 022;
Origin ID : C217734;
concept_is_in_subset
- has_target
