Preferred Label : Anti-TREM2 Monoclonal Antibody EOS006215;
NCIt synonyms : Anti-TREM2 Monoclonal Antibody EOS-215;
NCIt definition : A human monoclonal antibody targeting triggering receptor expressed on myeloid cells
2 (TREM2; TREM-2), with potential immunomodulating and antineoplastic activities.
Upon administration, anti-TREM2 monoclonal antibody EOS006215 targets and binds to
TREM2 located on immunosuppressive tumor-associated myeloid cells within the tumor
microenvironment (TME), including tumor associated macrophages (TAMs). This blocks
the binding of TREM2 ligands, such as phosphatidylserine (PS) and low-density lipoprotein
(LDL), to TREM2, thereby inhibiting TREM2 multimerization and TREM2-mediated downstream
signaling. This alters the TME and activates cytotoxic T-lymphocytes (CTLs), natural
killer (NK) cells and M1-like macrophages, resulting in anti-tumor immune responses
and tumor cell destruction. TREM2, an immunoglobulin (Ig) superfamily transmembrane
protein, is expressed within the TME and is associated with poorer patient outcomes.;
Molecule name : EOS-006215; EOS-215; EOS 006215; EOS 215;
Origin ID : C217361;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
