Preferred Label : Anti-TM4SF1 Antibody-drug Conjugate AGX101;
NCIt synonyms : Anti-TM4SF1 ADC AGX101; Anti-TM4SF1 Nuclear-delivered Antibody-Drug Conjugate AGX101; ADC AGX101; Anti-TM4SF1 ND-ADC AGX101;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) transmembrane 4 L six family member 1 (TM4SF1)
site-specifically conjugated to a maytansinoid tubulin inhibitor, with potential antineoplastic
activity. Upon administration of anti-TM4SF1 ADC AGX101, the antibody moiety targets
and binds to TM4SF1 expressed on tumor cells and tumor-associated vascular endothelium.
Upon binding and the internalization of TM4SF1 via microtubules to the nucleus, the
maytansinoid tubulin inhibitor is delivered to the nucleus of tumor cells. The maytansinoid
binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting
in the inhibition of both cell division and cell growth of TM4SF1-expressing tumor
cells and tumor-associated vascular endothelium. TM4SF1 plays a key role in the regulation
of cell development, activation, growth and motility, and is overexpressed by a variety
of tumor cells.;
Molecule name : AGX-101; AGX 101;
Origin ID : C217325;
concept_is_in_subset
- has_target
