Preferred Label : Allogeneic TGFBR2 KO CAR27/IL-15-expressing NK Cells;
NCIt synonyms : Allogeneic TGFBR2 KO CAR27/IL-15-expressing Natural Killer Cells; TGFBR2 KO CAR27/IL-15 NK Cells; TGFBR2 KO CAR27/IL-15 NKs; TGFBR2 Knockout CAR27/IL-15 NK Cells;
NCIt definition : A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells
(NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific
for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70)
and expressing the cytokine interleukin-15 (IL-15) and in which the gene transforming
growth factor-beta receptor II (TGFbRII; TGFBR2) is deleted through clustered regularly
interspaced short palindromic repeats (CRISPR)-Cas 9 gene editing, with potential
immunostimulating and antineoplastic activities. Upon administration, the allogeneic
TGFBR2 KO CAR27/IL-15-expressing NK cells target, bind to and induce selective cytotoxicity
in CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27,
is overexpressed on the surfaces of various cancer cell types. IL-15 is a pro-survival
cytokine that promotes persistence of multiple lymphocyte lineages and potentiates
the immune response against tumor cells. As TGF-beta activation and release leads
to NK cell inactivation, deletion of the TGFBR2 gene increases the potency, persistence
and efficacy of the NK cells and enhances anti-tumor activity.;
Origin ID : C215857;
concept_is_in_subset
- has_target
