NADH-Cytochrome B5 Reductase 3

Preferred Label : NADH-Cytochrome B5 Reductase 3;

NCIt synonyms : Cytochrome B5 Reductase 3; EC 1.6.2.2; B5R; Diaphorase-1; Cytochrome B5 Reductase; CYB5R3;

NCIt definition : NADH-cytochrome b5 reductase 3 (301 aa, 34 kDa) is encoded by the human CYB5R3 gene. This protein plays a role in methemoglobin reduction, cholesterol synthesis and desaturation and elongation of fatty acids.;

NCIt note : NADH-cytochrome b5 reductase 3 is expressed as at least 3 isoforms due to alternative promoter usage and alternative splicing. This protein is expressed as endoplasmic reticulum or outer mitochondrial membrane-bound form in somatic cells and a cytoplasmic form in erythrocytes. The cytoplasmic form originates from an erythroid-specific promoter and is missing the N-terminal myristylation consensus sequence. (OMIM and UniProt);

Details

Origin ID

C215833;

OMIM relation
- Cytochrome b5 reductase 3 [OMIM gene]
gene_encodes_gene_product
- CYB5R3 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Outer Mitochondrial Membrane [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amino and Nucleotide Sugars Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Biosynthetic Process [NCIt concept]
- Fatty Acid Metabolism [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

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