Duocarmycin Antineoplastic Antibiotic

Preferred Label : Duocarmycin Antineoplastic Antibiotic;

NCIt synonyms : Duocarmycins; Duocarmycin Antibiotic;

NCIt definition : A spirocyclopropylhexadienone-containing antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. Duocarmycin antibiotics alkylate DNA by binding to adenine-thymine (A-T)- rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.;

Details

Origin ID

C2156;

UMLS CUI

C1512091;

Automatic exact mappings (from CISMeF team)
- duocarmycin A [MeSH Supplementary Concept]
- duocarmycin A [MeSH concept]
Currated CISMeF NLP mapping
- Duocarmycins [MeSH concept]
- Duocarmycins [MeSH Descriptor]
Semantic type(s)
- Antibiotic [UMLS semantic type]
UMLS correspondences (same concept)
- Duocarmycins [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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