ALK-Positive Lung Non-Small Cell Carcinoma

Preferred Label : ALK-Positive Lung Non-Small Cell Carcinoma;

NCIt synonyms : ALK-Positive NSCLC; ALK NSCLC;

NCIt definition : A lung non-small cell carcinoma (NSCLC) characterized by the presence of rearrangements of the ALK gene that lead to activation of ALK kinase and ALK driven tumor formation. These rearrangements were initially identified as EML4-ALK fusions, but a variety of other ALK gene fusions were subsequently identified. Approximately 5% of patients with NSCLC carry ALK rearrangements and are highly sensitive to treatment with ALK inhibitors.;

Neoplastic status : Malignant;

Details

Origin ID

C215346;

Disease excludes abnormal cell
- Malignant Epithelial Small Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Excludes anatomical site(s)
- Neck [NCIt concept]
- Skin [NCIt concept]
Has associated anatomic sites
- Lung [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Premalignant Lesion [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- ALK Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Lung [NCIt concept]
disease_mapped_to_gene
- ALK Gene [NCIt concept]
- EML4/ALK Fusion Gene [NCIt concept]
- TP53 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- TP53 Gene Inactivation [NCIt concept]
pathogenesis_of_disease_involves_gene
- ALK Gene [NCIt concept]
- ALK wt Allele [NCIt concept]
- ALKATI Allele [NCIt concept]
- EML4/ALK Fusion Gene [NCIt concept]
- EML4/ALK Fusion Gene Variant 1 [NCIt concept]
- EML4/ALK Fusion Gene Variant 2 [NCIt concept]
- EML4/ALK Fusion Gene Variant 3a [NCIt concept]
- EML4/ALK Fusion Gene Variant 3b [NCIt concept]
- EML4/ALK Fusion Gene Variant 4 [NCIt concept]
- EML4/ALK Fusion Gene Variant 5a [NCIt concept]
- EML4/ALK Fusion Gene Variant 5b [NCIt concept]

Keyword's position in hierarchy(ies) :

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