Preferred Label : Anti-5T4/Exatecan Antibody-drug Conjugate TUB-030;
NCIt synonyms : Anti-5T4 Antibody-drug Conjugate TUB-030; Anti-5T4/Exatecan ADC TUB-030; Anti-5T4 ADC TUB-030;
NCIt definition : An antibody-drug conjugate (ADC) composed of a Fc-silenced, humanized, immunoglobulin
G1 (IgG1) monoclonal antibody directed against the oncofetal antigen 5T4 and site-specifically
conjugated, via a cleavable linker, to the cytotoxic agent and DNA topoisomerase I
inhibitor exatecan, with potential antineoplastic activity. Upon administration of
anti-5T4/exatecan ADC TUB-030, the anti-5T4 antibody moiety selectively targets and
binds to cells expressing 5T4. After internalization and cleavage within the tumor
cell, exatecan is released and inhibits DNA topoisomerase I activity, thereby inhibiting
DNA replication and resulting in DNA damage, cell cycle arrest and apoptosis in tumor
cells overexpressing 5T4. In addition, TUB-030 induces a bystander effect, thereby
killing neighboring tumor cells that don't necessarily express 5T4 in the tumor environment
(TME). 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer
cell types while its expression is limited in normal adult tissues; its expression
is correlated with increased invasiveness.;
Molecule name : TUB-030; TUB 030;
Origin ID : C215150;
concept_is_in_subset
- has_target
