Preferred Label : Anti-MAGE-A4/Anti-CD3 Bispecific Antibody RO7617991;
NCIt synonyms : MAGE-A4 x CD3 Bispecific Antibody RO7617991; Anti-MAGE-A4/CD3 Bispecific Antibody RO7617991;
NCIt definition : A bispecific T-cell engaging antibody directed against both the tumor-associated antigen
(TAA) melanoma-associated antigen A4 (MAGE-A4) and T-cell surface antigen CD3, with
potential immunostimulating and antineoplastic activities. Upon administration, anti-MAGE-A4/anti-CD3
bispecific antibody RO7617991 simultaneously binds to both CD3 on cytotoxic T-lymphocytes
(CTLs) and MAGE-A4 on MAGE-A4-expressing tumor cells. This activates and redirects
CTLs to MAGE-A4-expressing tumor cells, which results in the CTL-mediated cell death
of MAGE-A4-expressing tumor cells. MAGE-A4 is overexpressed by a variety of cancer
cell types.;
Molecule name : RO-7617991; RO 7617991;
Origin ID : C215082;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
