Preferred Label : Anti-DLL3 CAR-NK Cells SNC-115;
NCIt synonyms : Anti-DLL3 CAR NK Cells SNC-115; Anti-DLL3 CAR-Natural Killer Cells SNC-115;
NCIt definition : A preparation of natural killer (NK) cells engineered to express a chimeric antigen
receptor (CAR) specific for the tumor-associated antigen (TAA) delta-like protein
3 (DLL3), with potential immunomodulating and antineoplastic activities. Upon administration,
anti-DLL3 CAR-NK cells SNC-115 recognize, bind to and induce selective cytotoxicity
in DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on
a variety of cancer cell types. It plays a key role in embryonic development and in
tumor initiation and proliferation.;
Molecule name : SNC-115; SNC 115;
Origin ID : C215080;
concept_is_in_subset
- has_target
