Preferred Label : Indium In 111-ABD147;
NCIt synonyms : 111In-ABD147;
NCIt definition : A radioimmunoconjugate consisting of ABD147, an antibody fragment directed against
the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) conjugated to the radioisotope
indium In 111 (111In), with potential imaging activity. Upon administration of indium
In 111-ABD147, ABD147 targets and binds to DLL3 on DLL3-expressing tumor cells. Upon
uptake and imaging, DLL3-expressing tumor cells can be visualized. This allows the
assessment of DLL3 expression on tumor cells as well as tumor uptake of the agent.
DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types.
It plays a key role in embryonic development and in tumor initiation and proliferation.;
Origin ID : C214898;
concept_is_in_subset
- has_target
