Preferred Label : Actinium Ac 225-ABD147;
NCIt synonyms : 225Ac-ABD147;
NCIt definition : A radioimmunoconjugate consisting of ABD147, an antibody fragment directed against
the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) conjugated with a linker-chelator
to the alpha-emitting radioisotope actinium Ac 225 (225Ac), with potential antineoplastic
activity. Upon administration of actinium Ac 225-ABD147, ABD147 targets and binds
to DLL3 on DLL3-expressing tumor cells. Upon binding, the radioisotope moiety delivers
a cytotoxic dose of alpha radiation to DLL3-expressing tumor cells. DLL3, a Notch
pathway protein, is overexpressed on a variety of cancer cell types. It plays a key
role in embryonic development and in tumor initiation and proliferation.;
Origin ID : C214889;
concept_is_in_subset
- has_target
