Preferred Label : Ningetinib;
NCIt synonyms : CT-053-PTSA Free Base; CT053PTSA Free Base; CT-053 Free Base;
NCIt definition : An orally available inhibitor of the receptor tyrosine kinases c-MET/hepatocyte growth
factor receptor (HGFR), vascular endothelial growth factor receptor 2 (VEGFR2 KDR),
Axl (UFO), Mer, and Fms-like tyrosine kinase 3 (Flt3; CD135; STK1; FLK2), with antineoplastic
activity. Upon administration, ningetinib binds to a variety of kinases, including
c-Met, VEGFR2, Axl, Mer and Flt3, thereby inhibiting their signaling pathways. This
inhibits growth, angiogenesis and metastasis of tumor cells that overexpress these
kinases. c-Met, VEGFR2, Axl, Mer and Flt3 are overexpressed by many tumor cell types
and play key roles in tumor cell proliferation, survival, invasion and metastasis.;
UNII : PW3Q92Z6A4;
CAS number : 1394820-69-9;
Origin ID : C214441;
concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
