Preferred Label : Ningetinib Tosylate;
NCIt synonyms : CT-053 Tosylate;
NCIt definition : The tosylate salt form of ningetinib, an orally available inhibitor of the receptor
tyrosine kinases c-MET/hepatocyte growth factor receptor (HGFR), vascular endothelial
growth factor receptor 2 (VEGFR2 KDR), Axl (UFO), Mer, and Fms-like tyrosine kinase
3 (Flt3; CD135; STK1; FLK2), with antineoplastic activity. Upon administration, ningetinib
binds to a variety of kinases, including c-Met, VEGFR2, Axl, Mer and Flt3, thereby
inhibiting their signaling pathways. This inhibits growth, angiogenesis and metastasis
of tumor cells that overexpress these kinases. c-Met, VEGFR2, Axl, Mer and Flt3 are
overexpressed by many tumor cell types and play key roles in tumor cell proliferation,
survival, invasion and metastasis.;
UNII : R7I5725FES;
CAS number : 1394820-77-9;
Molecule name : CT-053-PTSA;
NCI Metathesaurus CUI : CL551136;
Origin ID : C148529;
UMLS CUI : C4725104;
Semantic type(s)
- concept_is_in_subset
