Preferred Label : Sutetinib;
NCIt synonyms : (2E)-N-(3-Cyano-7-ethoxy-4-((3-ethynylphenyl)amino)-6-quinolinyl)-4-(dimethylamino)-2-butenamide; 2-Butenamide, N-(3-cyano-7-ethoxy-4-((3-ethynylphenyl)amino)-6-quinolinyl)-4-(dimethylamino)-,
(2E)-;
NCIt definition : An orally bioavailable, mutant-selective, epidermal growth factor receptor (EGFR)
inhibitor, with potential antineoplastic activity. Upon oral administration, sutetinib
selectively targets, irreversibly binds to, and inhibits the activity of various EGFR
mutations, including the less common mutations L861Q, G719X, and S768I. This prevents
EGFR-mediated signaling in susceptible tumor cells. This may both induce cell death
and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine
kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation
and survival.;
UNII : 538A7S75AB;
CAS number : 1259519-20-4;
Origin ID : C213792;
concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
